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Issue 27, 2018
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Synthesis of N-arylsulfonamides via Fe-promoted reaction of sulfonyl halides with nitroarenes in an aqueous medium

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Abstract

A fascinating Fe-promoted protocol for the synthesis of N-arylsulfonamides has been developed. Starting from commercially available nitroarenes and sulfonyl chlorides, moderate to excellent yields of the corresponding N-arylsulfonamides can be obtained. In particular, Fe dust serves as the sole reductant in the transformation and it can be easily performed on a large scale.

Graphical abstract: Synthesis of N-arylsulfonamides via Fe-promoted reaction of sulfonyl halides with nitroarenes in an aqueous medium

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Publication details

The article was received on 18 May 2018, accepted on 20 Jun 2018 and first published on 27 Jun 2018


Article type: Paper
DOI: 10.1039/C8OB01172A
Citation: Org. Biomol. Chem., 2018,16, 5016-5020
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    Synthesis of N-arylsulfonamides via Fe-promoted reaction of sulfonyl halides with nitroarenes in an aqueous medium

    J. Jiang, S. Zeng, D. Chen, C. Cheng, W. Deng and J. Xiang, Org. Biomol. Chem., 2018, 16, 5016
    DOI: 10.1039/C8OB01172A

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