Issue 27, 2018

Synthesis of N-arylsulfonamides via Fe-promoted reaction of sulfonyl halides with nitroarenes in an aqueous medium

Abstract

A fascinating Fe-promoted protocol for the synthesis of N-arylsulfonamides has been developed. Starting from commercially available nitroarenes and sulfonyl chlorides, moderate to excellent yields of the corresponding N-arylsulfonamides can be obtained. In particular, Fe dust serves as the sole reductant in the transformation and it can be easily performed on a large scale.

Graphical abstract: Synthesis of N-arylsulfonamides via Fe-promoted reaction of sulfonyl halides with nitroarenes in an aqueous medium

Supplementary files

Article information

Article type
Paper
Submitted
18 May 2018
Accepted
20 Jun 2018
First published
27 Jun 2018

Org. Biomol. Chem., 2018,16, 5016-5020

Synthesis of N-arylsulfonamides via Fe-promoted reaction of sulfonyl halides with nitroarenes in an aqueous medium

J. Jiang, S. Zeng, D. Chen, C. Cheng, W. Deng and J. Xiang, Org. Biomol. Chem., 2018, 16, 5016 DOI: 10.1039/C8OB01172A

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