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Issue 27, 2018
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Total synthesis and structural revision of an isopanepoxydone analog isolated from Lentinus strigellus

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Abstract

Asymmetric total synthesis of compound 1, as a proposed molecular structure of a natural product, in 11 steps is described. The inconsistency of the characterization data between our synthesized sample and the natural product prompted us to propose a different molecular structure as compound 2 and accordingly accomplish total synthesis in 9 steps and confirm the structural revision of this natural product. Both total syntheses feature highly regio- and diastereoselective epoxidation, Stille cross-coupling and cross-metathesis.

Graphical abstract: Total synthesis and structural revision of an isopanepoxydone analog isolated from Lentinus strigellus

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Publication details

The article was received on 18 May 2018, accepted on 20 Jun 2018 and first published on 20 Jun 2018


Article type: Paper
DOI: 10.1039/C8OB01168K
Citation: Org. Biomol. Chem., 2018,16, 5043-5049
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    Total synthesis and structural revision of an isopanepoxydone analog isolated from Lentinus strigellus

    Y. Man, S. Fu, J. Chen and B. Liu, Org. Biomol. Chem., 2018, 16, 5043
    DOI: 10.1039/C8OB01168K

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