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Unprecedented Synthesis of 1,2,3-Triazolo-Cinnolinone via Sonogashira Coupling and Intramolecular Cyclization

Abstract

Copper mediated an unprecedented one pot sequential synthesis of 1,2,3-triazolo cinnolinone derivatives from 2-halo-phenyl triazoles and terminal alkynes has been reported. Under optimized reaction conditions, a broad range of substituted triazoles and alkynes were found to participate in this transformation, thus affording unknown 1,2,3-triazolo cinnolinone derivatives in moderate to excellent yield. This method proceeds through sequential C-C coupling followed by annulation cascade sequence in the same vessel under atmospheric air as the sole oxidant, thus representing a simple, efficient and atom economical approach to aza-cinnolinones.

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Publication details

The article was received on 17 May 2018, accepted on 12 Jun 2018 and first published on 12 Jun 2018


Article type: Paper
DOI: 10.1039/C8OB01152D
Citation: Org. Biomol. Chem., 2018, Accepted Manuscript
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    Unprecedented Synthesis of 1,2,3-Triazolo-Cinnolinone via Sonogashira Coupling and Intramolecular Cyclization

    A. Kumar, D. K. Tiwari, B. Sridhar and P. R. Likhar, Org. Biomol. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8OB01152D

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