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Rhodium-catalyzed regioselective C8-H amination of quinoline N-oxides with trifluoroacetamide at room temperature

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Abstract

A facile and efficient protocol for rhodium-catalyzed amination of quinoline N-oxides at the C-8 position using simple and commercially available trifluoroacetamide as the amino source has been developed, which proceeds with perfect regioselectivity at room temperature and short reaction times. This catalytic system is highly convenient on a gram scale. The desired products feature diverse functional group tolerance with good to excellent yields.

Graphical abstract: Rhodium-catalyzed regioselective C8-H amination of quinoline N-oxides with trifluoroacetamide at room temperature

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Publication details

The article was received on 11 May 2018, accepted on 04 Jun 2018 and first published on 04 Jun 2018


Article type: Paper
DOI: 10.1039/C8OB01108G
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Rhodium-catalyzed regioselective C8-H amination of quinoline N-oxides with trifluoroacetamide at room temperature

    C. You, T. Yuan, Y. Huang, C. Pi, Y. Wu and X. Cui, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB01108G

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