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Issue 27, 2018
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(2-Fluoroallyl)boronates: new reagents for diastereoselective 2-fluoroallylboration of aldehydes

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Abstract

A Pd-catalyzed borylation of 2-fluoroallyl chlorides with B2pin2 in the presence of [(2-MeAll)PdCl]2/TMEDA or [(2-MeAll)Pd(IPr)Cl] was developed to afford (2-fluoroallyl)pinacolboronates with high Z-selectivity. The products proved to be useful for anti-selective 2-fluoroallylboration of aromatic and aliphatic aldehydes.

Graphical abstract: (2-Fluoroallyl)boronates: new reagents for diastereoselective 2-fluoroallylboration of aldehydes

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Publication details

The article was received on 11 May 2018, accepted on 21 Jun 2018 and first published on 21 Jun 2018


Article type: Communication
DOI: 10.1039/C8OB01103F
Citation: Org. Biomol. Chem., 2018,16, 4963-4967
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    (2-Fluoroallyl)boronates: new reagents for diastereoselective 2-fluoroallylboration of aldehydes

    M. A. Novikov and O. M. Nefedov, Org. Biomol. Chem., 2018, 16, 4963
    DOI: 10.1039/C8OB01103F

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