Jump to main content
Jump to site search


Streamlined chemoenzymatic total synthesis of prioritized ganglioside cancer antigens

Author affiliations

Abstract

A highly efficient streamlined chemoenzymatic strategy for total synthesis of four prioritized ganglioside cancer antigens GD2, GD3, fucosyl GM1, and GM3 from commercially available lactose and phytosphingosine is demonstrated. Lactosyl sphingosine (LacβSph) was chemically synthesized (on a 13 g scale), subjected to sequential one-pot multienzyme (OPME) glycosylation reactions with facile C18-cartridge purification, followed by improved acylation conditions to form target gangliosides, including fucosyl GM1 which has never been synthesized before.

Graphical abstract: Streamlined chemoenzymatic total synthesis of prioritized ganglioside cancer antigens

Back to tab navigation

Supplementary files

Publication details

The article was received on 09 May 2018, accepted on 10 May 2018 and first published on 14 May 2018


Article type: Communication
DOI: 10.1039/C8OB01087K
Citation: Org. Biomol. Chem., 2018, Advance Article
  •   Request permissions

    Streamlined chemoenzymatic total synthesis of prioritized ganglioside cancer antigens

    H. Yu, A. Santra, Y. Li, J. B. McArthur, T. Ghosh, X. Yang, P. G. Wang and X. Chen, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB01087K

Search articles by author

Spotlight

Advertisements