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Issue 27, 2018
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Auto-oxidation promoted sp3 C–H arylation of glycine derivatives

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Abstract

An auto-oxidation promoted sp3 C–H arylation reaction between N-aryl glycine derivatives and electron-rich arenes, leading to the formation of N-aryl α-aryl α-amino acid derivatives, is described. This atom-economical and environmentally benign reaction proceeds smoothly under mild reaction conditions and requires only Brønsted acid and oxygen (balloon). A plausible radical involved mechanism is proposed.

Graphical abstract: Auto-oxidation promoted sp3 C–H arylation of glycine derivatives

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Publication details

The article was received on 08 May 2018, accepted on 19 Jun 2018 and first published on 19 Jun 2018


Article type: Paper
DOI: 10.1039/C8OB01068D
Citation: Org. Biomol. Chem., 2018,16, 4985-4989
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    Auto-oxidation promoted sp3 C–H arylation of glycine derivatives

    Y. Wei, J. Wang, Y. Wang, X. Yao, C. Yang and C. Huo, Org. Biomol. Chem., 2018, 16, 4985
    DOI: 10.1039/C8OB01068D

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