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Issue 28, 2018
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A new route to substituted furocoumarins via copper-catalyzed cyclization between 4-hydroxycoumarins and ketoximes

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Abstract

A new route to substituted furocoumarins via copper-catalyzed cyclization between 4-hydroxycoumarins and ketoximes was developed. CuBr2 exhibited higher activity than other copper salts, affording the desired furocoumarins in high yields. The transformation proceeded readily in the absence of stoichiometric external oxidants. The significance of this synthetic strategy would be (1) the easily available starting materials; (2) low cost catalyst CuBr2; and (3) being without stoichiometric external oxidants. This protocol is complementary to previous approaches in the synthesis of substituted furocoumarins.

Graphical abstract: A new route to substituted furocoumarins via copper-catalyzed cyclization between 4-hydroxycoumarins and ketoximes

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Publication details

The article was received on 07 May 2018, accepted on 25 Jun 2018 and first published on 02 Jul 2018


Article type: Communication
DOI: 10.1039/C8OB01064A
Citation: Org. Biomol. Chem., 2018,16, 5086-5089
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    A new route to substituted furocoumarins via copper-catalyzed cyclization between 4-hydroxycoumarins and ketoximes

    T. A. To, Y. H. Vo, A. T. Nguyen, A. N. Q. Phan, T. Truong and N. T. S. Phan, Org. Biomol. Chem., 2018, 16, 5086
    DOI: 10.1039/C8OB01064A

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