Jump to main content
Jump to site search


C–H alkylation reactions of indoles mediated by Pd(II) and norbornene: applications and recent developments

Author affiliations

Abstract

The Catellani reaction enables an ortho-C–H activation based on oxidative addition of Pd(0) and an intermediary carbopalladation of norbornene. Among its variants, the recently developed C2-selective alkylation of indoles is particular as it employs Pd(II) as the source of palladium. This review describes the mechanistic background of this transformation. Applications in total synthesis and in the synthesis of biologically relevant molecules are illustrated and further developments of the method are discussed.

Graphical abstract: C–H alkylation reactions of indoles mediated by Pd(ii) and norbornene: applications and recent developments

Back to tab navigation

Publication details

The article was received on 02 May 2018, accepted on 04 Jul 2018 and first published on 04 Jul 2018


Article type: Review Article
DOI: 10.1039/C8OB01025K
Citation: Org. Biomol. Chem., 2018, Advance Article
  •   Request permissions

    C–H alkylation reactions of indoles mediated by Pd(II) and norbornene: applications and recent developments

    M. Wegmann, M. Henkel and T. Bach, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB01025K

Search articles by author

Spotlight

Advertisements