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Issue 27, 2018
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Palladium-catalyzed selective synthesis of 3,4-dihydroquinazolines from electron-rich arylamines, electron-poor arylamines and glyoxalates

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Abstract

A simple palladium-catalyzed selective synthesis of structurally diverse 3,4-dihydroquinazolines from electron-rich arylamines, electron-poor arylamines and glyoxalates has been developed under mild conditions. This reaction is carried out in a tandem manner constituted by the condensation of arylamines and glyoxalates, the selective Diels–Alder cycloaddition and oxidation processes, in which 4-nitrothiophenol was used as the key ligand.

Graphical abstract: Palladium-catalyzed selective synthesis of 3,4-dihydroquinazolines from electron-rich arylamines, electron-poor arylamines and glyoxalates

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Publication details

The article was received on 30 Apr 2018, accepted on 24 Jun 2018 and first published on 25 Jun 2018


Article type: Paper
DOI: 10.1039/C8OB01005F
Citation: Org. Biomol. Chem., 2018,16, 5050-5054
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    Palladium-catalyzed selective synthesis of 3,4-dihydroquinazolines from electron-rich arylamines, electron-poor arylamines and glyoxalates

    C. Wu, J. Wang, X. Zhang, G. Jia, Z. Cao, Z. Tang, X. Yu, X. Xu and W. He, Org. Biomol. Chem., 2018, 16, 5050
    DOI: 10.1039/C8OB01005F

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