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A ruthenium-catalyzed alkenylation–annulation approach for the synthesis of indazole derivatives via C–H bond activation

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Abstract

Ruthenium catalyzed oxidative alkenylation of N-aryl pyridazinediones and N-aryl phthalazinediones with acrylates and subsequent intramolecular cyclization of the resulting product in water as a green solvent were accomplished. Diverse derivatives of pyridazino[1,2-a]indazoles and indazolo[1,2-b]phthalazines were readily prepared in moderate to high yields by this methodology from easily accessible starting materials via cascade directed C–H bond activation/annulation reactions.

Graphical abstract: A ruthenium-catalyzed alkenylation–annulation approach for the synthesis of indazole derivatives via C–H bond activation

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Publication details

The article was received on 28 Apr 2018, accepted on 23 Jul 2018 and first published on 03 Aug 2018


Article type: Paper
DOI: 10.1039/C8OB00999F
Citation: Org. Biomol. Chem., 2018, Advance Article
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    A ruthenium-catalyzed alkenylation–annulation approach for the synthesis of indazole derivatives via C–H bond activation

    M. Gholamhosseyni and E. Kianmehr, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB00999F

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