Jump to main content
Jump to site search


Iron promoted C3–H nitration of 2H-indazole: direct access to 3-nitro-2H-indazoles

Author affiliations

Abstract

An efficient C3–H functionalization of indazole has been demonstrated. Notably, this method involves chelation-free radical C–H nitration on 2H-indazole. The radical mechanism was confirmed by control experiments and quantum chemical calculations. The synthetic utility has been proven by the synthesis of bio-relevant benzimidazoindazoles via reductive cyclization.

Graphical abstract: Iron promoted C3–H nitration of 2H-indazole: direct access to 3-nitro-2H-indazoles

Back to tab navigation

Supplementary files

Publication details

The article was received on 20 Apr 2018, accepted on 29 Jun 2018 and first published on 06 Jul 2018


Article type: Communication
DOI: 10.1039/C8OB00931G
Citation: Org. Biomol. Chem., 2018, Advance Article
  •   Request permissions

    Iron promoted C3–H nitration of 2H-indazole: direct access to 3-nitro-2H-indazoles

    A. Murugan, K. R. Gorantla, B. S. Mallik and D. S. Sharada, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB00931G

Search articles by author

Spotlight

Advertisements