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Stabilization of intermolecular i-motif by lipid modification of Cytosine-oligodeoxynucleotides

Abstract

This paper described the stabilization of intermolecular i-motif by lipophilic modification on the 3' terminus of oligonucleotide. The hydrophobic aliphatic chain connected at 3' terminus of trinucleotide (dC)3 promoted the formation of i-motif and significantly enhanced the quadruplex's stability. The impact of lipophilic modification on i-motif's thermal stability was studied by melting points and isothermal titration calometry. We found that alkyl chains contains more than 14 carbon atoms could elevate the i-motif structure's stability at a wide pH and concentration.

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Publication details

The article was received on 19 Apr 2018, accepted on 13 Jun 2018 and first published on 14 Jun 2018


Article type: Paper
DOI: 10.1039/C8OB00920A
Citation: Org. Biomol. Chem., 2018, Accepted Manuscript
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    Stabilization of intermolecular i-motif by lipid modification of Cytosine-oligodeoxynucleotides

    Y. Sun, Y. Ji, D. Wang, J. Wang and D. Liu, Org. Biomol. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8OB00920A

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