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Copper-catalyzed ambient-temperature decarboxylative annulation of isatins with amidine hydrochlorides: a facile access to 2-(1,3,5-triazin-2-yl)aniline derivatives

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Abstract

A copper-catalyzed cascade reaction using isatins and amidine hydrochlorides for the synthesis of 2-(1,3,5-triazin-2-yl)aniline derivatives has been developed. This reaction features commercially available starting materials, mild reaction conditions and good functional group tolerance.

Graphical abstract: Copper-catalyzed ambient-temperature decarboxylative annulation of isatins with amidine hydrochlorides: a facile access to 2-(1,3,5-triazin-2-yl)aniline derivatives

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Publication details

The article was received on 17 Apr 2018, accepted on 15 May 2018 and first published on 16 May 2018


Article type: Communication
DOI: 10.1039/C8OB00904J
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Copper-catalyzed ambient-temperature decarboxylative annulation of isatins with amidine hydrochlorides: a facile access to 2-(1,3,5-triazin-2-yl)aniline derivatives

    F. Jia, C. Xu, Y. Wang, Z. Chen, Y. Chen and A. Wu, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB00904J

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