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Issue 24, 2018
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The synthesis of multi-substituted pyrrolidinones via a direct [3 + 2] cycloaddition of azaoxyallyl cations with aromatic ethylenes

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Abstract

A novel [3 + 2] cycloaddition reaction of azaoxyallyl cations and aromatic ethylenes has been developed to afford multi-substituted pyrrolidinones in moderate to good yields. This method not only further expands the synthetic utility of α-halo hydroxamates, but also provides an alternative method for the synthesis of bioactive molecules containing pyrrolidinones.

Graphical abstract: The synthesis of multi-substituted pyrrolidinones via a direct [3 + 2] cycloaddition of azaoxyallyl cations with aromatic ethylenes

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Publication details

The article was received on 17 Apr 2018, accepted on 24 May 2018 and first published on 25 May 2018


Article type: Communication
DOI: 10.1039/C8OB00899J
Citation: Org. Biomol. Chem., 2018,16, 4439-4442
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    The synthesis of multi-substituted pyrrolidinones via a direct [3 + 2] cycloaddition of azaoxyallyl cations with aromatic ethylenes

    Y. Zhang, H. Ma, X. Liu, X. Cui, S. Wang, Z. Zhan, J. Pu and G. Huang, Org. Biomol. Chem., 2018, 16, 4439
    DOI: 10.1039/C8OB00899J

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