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Copper-catalyzed remote oxidation of alcohols initiated by radical difluoroalkylation of alkenes: facile access to difluoroalkylated carbonyl compounds

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Abstract

A Cu-catalyzed oxidation of alcohols triggered by the radical difluoroalkylation of alkenes has been developed, providing facile access to a series of difluoroalkylated ketones or aldehydes in moderate to high yields. The concurrent realization of the catalytic oxidation of alcohols and difluoroalkylation of alkenes enables a highly efficient and attractive method for organic synthesis.

Graphical abstract: Copper-catalyzed remote oxidation of alcohols initiated by radical difluoroalkylation of alkenes: facile access to difluoroalkylated carbonyl compounds

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Publication details

The article was received on 16 Apr 2018, accepted on 02 May 2018 and first published on 03 May 2018


Article type: Communication
DOI: 10.1039/C8OB00889B
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Copper-catalyzed remote oxidation of alcohols initiated by radical difluoroalkylation of alkenes: facile access to difluoroalkylated carbonyl compounds

    J. Zhang, W. Jin, C. Cheng and F. Luo, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB00889B

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