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Intramolecularly enhanced molecular tweezers with unusually strong binding for aromatic guests in unfavorable solvents

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Abstract

Molecular tweezers using aromatic interactions for binding normally work best in polar instead of nonpolar solvents due to the strong solvophobic effect in the binding. Inspired by biological receptors that utilize “delocalized binding interactions” remote from the binding interface to strengthen guest-binding, we constructed molecular tweezers that have a reversed solvent effect. As the direct aromatic binding interactions were weakened by nonpolar solvent, guest-triggered intrahost interactions between two strategically placed carboxylic acids became stronger and contributed to the binding.

Graphical abstract: Intramolecularly enhanced molecular tweezers with unusually strong binding for aromatic guests in unfavorable solvents

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Publication details

The article was received on 03 Apr 2018, accepted on 07 May 2018 and first published on 07 May 2018


Article type: Communication
DOI: 10.1039/C8OB00786A
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Intramolecularly enhanced molecular tweezers with unusually strong binding for aromatic guests in unfavorable solvents

    X. Xing and Y. Zhao, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB00786A

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