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Regioselective 5-exo-dig oxy-cyclization of 2-alkynylbenzamide for the synthesis of isobenzofuran-1-imines and isobenzofuran

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Abstract

A TBAB-mediated brominative 5-exo-dig oxy-cyclization of 2-alkynylbenzamide is described here for the synthesis of isobenzofuran-1-imines and isobenzofuran derivatives at room temperature with a high efficiency and a broad reaction scope. The resulting isobenzofuran derivatives are also applied for synthesising various substituted isobenzofuran derivatives.

Graphical abstract: Regioselective 5-exo-dig oxy-cyclization of 2-alkynylbenzamide for the synthesis of isobenzofuran-1-imines and isobenzofuran

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Publication details

The article was received on 03 Apr 2018, accepted on 30 May 2018 and first published on 31 May 2018


Article type: Paper
DOI: 10.1039/C8OB00779A
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Regioselective 5-exo-dig oxy-cyclization of 2-alkynylbenzamide for the synthesis of isobenzofuran-1-imines and isobenzofuran

    R. Wang, S. Yuan, J. Liu, J. Wu and G. Qiu, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB00779A

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