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Issue 20, 2018
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A homodinuclear cobalt complex for the catalytic asymmetric Michael reaction of β-ketoesters to nitroolefins

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Abstract

A homodinuclear Co2/aminophenol sulfonamide complex has been developed for the asymmetric Michael reaction of β-ketoesters with nitroolefins. This procedure is capable of tolerating a wide range of substrates and excellent results (up to 99% yield, >99 : 1 dr and 98% ee) can also be obtained. Moreover, the reaction could be carried out on a 50 mmol scale without any decrease in the enantioselectivity and reactivity. On the basis of the results of mechanistic studies, we proposed that the Co2/2a complex would be the active species and a possible catalytic cycle was described.

Graphical abstract: A homodinuclear cobalt complex for the catalytic asymmetric Michael reaction of β-ketoesters to nitroolefins

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Publication details

The article was received on 02 Apr 2018, accepted on 02 May 2018 and first published on 02 May 2018


Article type: Paper
DOI: 10.1039/C8OB00773J
Citation: Org. Biomol. Chem., 2018,16, 3841-3850
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    A homodinuclear cobalt complex for the catalytic asymmetric Michael reaction of β-ketoesters to nitroolefins

    G. Chen, G. Liang, Y. Wang, P. Deng and H. Zhou, Org. Biomol. Chem., 2018, 16, 3841
    DOI: 10.1039/C8OB00773J

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