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Ruthenium-catalyzed C–H allylation of arenes with allylic amines

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Abstract

The Ru-catalyzed pyridyl-directed C–H allylation of arenes with allylic amines has been developed. This reaction was carried out in the presence of 5 mol% of [Ru(p-cymene)Cl2]2 and 0.5 equiv. of AgOAc in CF3CH2OH at 75 °C, affording the allylated products of arenes in moderate to excellent yields. The method exhibits a wide scope of allylic amines and arenes and shows a good compatibility of functional groups. The pyrazolyl- and pyrimidyl-directed C–H allylation of arenes was also performed under the same conditions.

Graphical abstract: Ruthenium-catalyzed C–H allylation of arenes with allylic amines

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Publication details

The article was received on 26 Mar 2018, accepted on 06 May 2018 and first published on 07 May 2018


Article type: Paper
DOI: 10.1039/C8OB00723C
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Ruthenium-catalyzed C–H allylation of arenes with allylic amines

    R. Yan and Z. Wang, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB00723C

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