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Synthetic studies toward marine metabolite prorocentin-4: Synthesis of the C1–C23 fragment

Abstract

A synthetic study on the construction of the C1–C23 fragment of prorocentin-4, a novel linear polyketide is described. The synthetic highlights include acid catalyzed epoxide opening, Gilman reaction, Pd(OH)2 catalyzed transformation of primary propargylic alcohol into an aldehyde, Oxa-Michael cyclization, and Horner-Wadsworth-Emmons (HWE) olefination reaction as key steps.

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Publication details

The article was received on 14 Feb 2018, accepted on 24 Apr 2018 and first published on 10 May 2018


Article type: Paper
DOI: 10.1039/C8OB00388B
Citation: Org. Biomol. Chem., 2018, Accepted Manuscript
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    Synthetic studies toward marine metabolite prorocentin-4: Synthesis of the C1–C23 fragment

    S. Gowravaram, P. AnkiReddy and S. R. AnkiReddy, Org. Biomol. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8OB00388B

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