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Issue 20, 2018
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Metal-free photocatalyzed aerobic oxidative Csp3–H functionalization of glycine derivatives: one-step generation of quinoline-fused lactones

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Abstract

A metal-free aerobic oxidative dehydrogenative coupling/annulation tandem reaction of glycine derivatives to 2,3-dihydrofuran is disclosed. This process involves the synergistic performance of organic-dye-mediated photoredox catalysis and acid catalysis. This reaction provides rapid and facile access to a series of valuable quinoline-fused lactones at room temperature under an air atmosphere. Moreover, the reaction could be performed on a 20 mmol scale, without obvious reduction of the yield.

Graphical abstract: Metal-free photocatalyzed aerobic oxidative Csp3–H functionalization of glycine derivatives: one-step generation of quinoline-fused lactones

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Publication details

The article was received on 29 Jan 2018, accepted on 30 Apr 2018 and first published on 01 May 2018


Article type: Paper
DOI: 10.1039/C8OB00240A
Citation: Org. Biomol. Chem., 2018,16, 3816-3823
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    Metal-free photocatalyzed aerobic oxidative Csp3–H functionalization of glycine derivatives: one-step generation of quinoline-fused lactones

    Y. He, B. Yan, H. Tao, Y. Zhang and Y. Li, Org. Biomol. Chem., 2018, 16, 3816
    DOI: 10.1039/C8OB00240A

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