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Issue 18, 2018
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A highly efficient dual-diazonium reagent for protein crosslinking and construction of a virus-based gel

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Abstract

A new bench-stable reagent with double diazonium sites was designed and synthesized for protein crosslinking. Based on the highly efficient diazonium-Tyr coupling reaction, a direct mixture of the reagent and tobacco mosaic virus led to the formation of a new hydrogel, which could be degraded by chemicals and could be used to encapsulate small molecules for sustained release. Because plant viruses exhibit many chemical characteristics like protein labelling and nucleic acid packaging, the virus-based hydrogel will have large chemical space for further functionalization. Besides, this dual-diazonium reagent should be a generally useful crosslinker for chemical biology and biomaterials.

Graphical abstract: A highly efficient dual-diazonium reagent for protein crosslinking and construction of a virus-based gel

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Publication details

The article was received on 20 Jan 2018, accepted on 03 Apr 2018 and first published on 04 Apr 2018


Article type: Communication
DOI: 10.1039/C8OB00169C
Citation: Org. Biomol. Chem., 2018,16, 3353-3357
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    A highly efficient dual-diazonium reagent for protein crosslinking and construction of a virus-based gel

    D. Ma, J. Zhang, C. Zhang, Y. Men, H. Sun, L. Li, L. Yi and Z. Xi, Org. Biomol. Chem., 2018, 16, 3353
    DOI: 10.1039/C8OB00169C

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