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Issue 18, 2018
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O-Substituted hydroxyl amine reagents: an overview of recent synthetic advances

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Abstract

Reagents derived from hydroxylamines such as 2,4-dinitrophenylhydroxylamine (DPH), O-(diphenylphosphinyl)hydroxylamine (DPPH), hydroxylamine-O-sulfonic acid (HOSA) and other related reagents in which oxygen is substituted with good leaving groups recently showed remarkable potential as electrophilic aminating agents and as a source of the amino group. They facilitate stereo- and regioselective C–N, N–N, O–N, and S–N bond-formation reactions and intra-molecular cyclizations without the requirement of expensive metal catalysts. In this review we have discussed the important transformations achieved with these reagents.

Graphical abstract: O-Substituted hydroxyl amine reagents: an overview of recent synthetic advances

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Publication details

The article was received on 18 Jan 2018, accepted on 28 Mar 2018 and first published on 28 Mar 2018


Article type: Review Article
DOI: 10.1039/C8OB00146D
Citation: Org. Biomol. Chem., 2018,16, 3314-3327
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    O-Substituted hydroxyl amine reagents: an overview of recent synthetic advances

    S. Sabir, G. Kumar and J. L. Jat, Org. Biomol. Chem., 2018, 16, 3314
    DOI: 10.1039/C8OB00146D

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