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KI-catalyzed C–S bond formation via an oxidation relay strategy: efficient access to various α-thio-β-dicarbonyl compounds

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Abstract

An efficient and practical methodology to obtain α-thio-β-dicarbonyl compounds was presented under alkaline conditions via potassium iodide (KI) catalysis; various symmetrical/unsymmetrical 1,3-dicarbonyl compounds were obtained under an aerobic atmosphere in moderate to excellent yields, with good functional group tolerance. Notably, a widely used anti-inflammatory drug butazodine could be modified with our protocol, even on a gram scale.

Graphical abstract: KI-catalyzed C–S bond formation via an oxidation relay strategy: efficient access to various α-thio-β-dicarbonyl compounds

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Publication details

The article was received on 10 Jan 2018, accepted on 12 Feb 2018 and first published on 12 Feb 2018


Article type: Communication
DOI: 10.1039/C8OB00080H
Citation: Org. Biomol. Chem., 2018, Advance Article
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    KI-catalyzed C–S bond formation via an oxidation relay strategy: efficient access to various α-thio-β-dicarbonyl compounds

    Y. Jiang, J. Zou, L. Huang, X. Peng, J. Deng, L. Zhu, Y. Yang, Y. Feng, X. Zhang and Z. Wang, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB00080H

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