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Issue 1, 2018
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Negishi cross-couplings in the synthesis of amino acids

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Abstract

The Negishi cross-coupling is a powerful C–C bond-forming reaction widely utilised in many areas of organic synthesis. This review details the use of Negishi cross-couplings in the synthesis of unnatural amino acids. The application of this reaction in the preparation of aromatic, heteroaromatic, and, complex amino acid derivatives are reviewed and presented herein.

Graphical abstract: Negishi cross-couplings in the synthesis of amino acids

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Publication details

The article was received on 31 Oct 2017, accepted on 27 Nov 2017 and first published on 27 Nov 2017


Article type: Review Article
DOI: 10.1039/C7OB02682J
Citation: Org. Biomol. Chem., 2018,16, 10-20
  • Open access: Creative Commons BY license
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    Negishi cross-couplings in the synthesis of amino acids

    W. D. G. Brittain and S. L. Cobb, Org. Biomol. Chem., 2018, 16, 10
    DOI: 10.1039/C7OB02682J

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