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Responsive upconversion nanoprobe for monitoring and inhibition of EBV-associated cancers via targeting EBNA1

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Abstract

Non-responsive emission enhancement is the disadvantage of upconversion nanomaterials (UCNM) when compared with conventional organic based agents for molecular imaging. We herein show a new strategy by conjugating NaGdF4:Yb3+,Er3+@NaGdF4 (UCNP) with peptides to achieve responsive UC emission enhancement upon binding to a targeted protein – EBNA1. EBNA1 is a well-known viral latent protein for the EBV-associated cancer. Peptide-coating of the functionalized core–shell nanoparticle diminishes upconverted emission intensity drastically. However, the peptide-coated UCNP shows selective and responsive UC emission enhancement via aggregation with the targeted protein. This phenomenon paves a new way for UCNM in molecular imaging.

Graphical abstract: Responsive upconversion nanoprobe for monitoring and inhibition of EBV-associated cancers via targeting EBNA1

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Publication details

The article was received on 21 Jun 2018, accepted on 01 Aug 2018 and first published on 06 Aug 2018


Article type: Paper
DOI: 10.1039/C8NR05015E
Citation: Nanoscale, 2018, Advance Article
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    Responsive upconversion nanoprobe for monitoring and inhibition of EBV-associated cancers via targeting EBNA1

    S. Zha, Y. H. Fung, H. Chau, P. Ma, J. Lin, J. Wang, L. S. Chan, G. Zhu, H. L. Lung and K. Wong, Nanoscale, 2018, Advance Article , DOI: 10.1039/C8NR05015E

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