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Enzymatic film formation of nature-derived phenolic amines

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Abstract

An enzyme-instructed method is developed for material-independent, cytocompatible coating of phenolic amines, inspired by melanogenesis found in nature. Tyrosinase-based film formation proceeds smoothly in an aqueous solution at neutral pH, and can use various phenolic amines including catecholamines, such as tyrosine, tyramine, dopamine, norepinephrine, and DOPA, as a coating precursor. Compared with polydopamine coating, the method is fast and efficient, and forms uniform films. Its high cytocompatibility is advantageously applied to cell-surface engineering, where chemically labile Jurkat cells are coated individually without any noticeable decrease in viability. Considering the huge potential of polyphenolic-based coatings, the strategy developed herein will provide an advanced tool for manipulating biological entities, including living cells, in biomedical and medicinal applications.

Graphical abstract: Enzymatic film formation of nature-derived phenolic amines

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Publication details

The article was received on 28 May 2018, accepted on 27 Jun 2018 and first published on 28 Jun 2018


Article type: Communication
DOI: 10.1039/C8NR04312D
Citation: Nanoscale, 2018, Advance Article
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    Enzymatic film formation of nature-derived phenolic amines

    J. Y. Kim, W. I. Kim, W. Youn, J. Seo, B. J. Kim, J. K. Lee and I. S. Choi, Nanoscale, 2018, Advance Article , DOI: 10.1039/C8NR04312D

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