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The aerolysin nanopore: from peptidomic to genomic applications

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Abstract

The aerolysin pore (ARP) is a newly emerging nanopore that has been extensively used for peptide and protein sensing. Recently, several groups have explored the application of ARP in detecting genetic and epigenetic markers. This brief review summarizes the current applications of ARP, progressing from peptidomic to genomic detection; the recently reported site-directed mutagenesis of ARP; and new genomic DNA sensing approaches, and their advantages and disadvantages. This review will also discuss the perspectives and future applications of ARP for nucleic acid sequencing and biomolecule sensing.

Graphical abstract: The aerolysin nanopore: from peptidomic to genomic applications

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Publication details

The article was received on 25 May 2018, accepted on 25 Jun 2018 and first published on 25 Jun 2018


Article type: Minireview
DOI: 10.1039/C8NR04255A
Citation: Nanoscale, 2018, Advance Article
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    The aerolysin nanopore: from peptidomic to genomic applications

    Y. Wang, L. Gu and K. Tian, Nanoscale, 2018, Advance Article , DOI: 10.1039/C8NR04255A

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