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In situ gold nanoparticle growth on polydopamine-coated 3D-printed scaffolds improves osteogenic differentiation for bone tissue engineering applications: in vitro and in vivo studies

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Abstract

In this study, we designed scaffolds coated with gold nanoparticles (GNPs) grown on a polydopamine (PDA) coating of a three-dimensional (3D) printed polycaprolactone (PCL) scaffold. Our results demonstrated that the scaffolds developed here may represent an innovative paradigm in bone tissue engineering by inducing osteogenesis as a means of remodeling and healing bone defects.

Graphical abstract: In situ gold nanoparticle growth on polydopamine-coated 3D-printed scaffolds improves osteogenic differentiation for bone tissue engineering applications: in vitro and in vivo studies

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Publication details

The article was received on 18 May 2018, accepted on 14 Jul 2018 and first published on 30 Jul 2018


Article type: Communication
DOI: 10.1039/C8NR04037K
Citation: Nanoscale, 2018, Advance Article
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    In situ gold nanoparticle growth on polydopamine-coated 3D-printed scaffolds improves osteogenic differentiation for bone tissue engineering applications: in vitro and in vivo studies

    S. J. Lee, H. Lee, S. Kim, J. M. Seok, J. H. Lee, W. D. Kim, I. K. Kwon, S. Park and S. A. Park, Nanoscale, 2018, Advance Article , DOI: 10.1039/C8NR04037K

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