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Noninvasive real-time monitoring of local drug release using nano Au-absorbed self-decomposable SiO2 carriers

Abstract

Real time monitoring of drug release at specific local sites by non-invasive imaging method is critical in patient-specific drug administration in order to avoid insufficient or excess drug dosing. In the present work, we designed a specific carrier system for such a purpose using self-decomposable SiO2 nanoparticles (NPs) with drug being loaded in the center and AuNPs on the SiO2 NPs as the imaging agent. We discovered a correlation between the drug release from the carrier and the morphological evolution of AuNPs, which also left the carrier and changed their aggregation states along with the drug release process. This finding enabled the real time monitoring the drug release at local sites (e.g. tumor) in a quantitative manner by recording the CT signal evolution of the AuNPs, as demonstrated in vivo using mice bearing Colo-205 xenografts. The present work provided a promising platform for non-invasive real time tracking on the localized drug release, enabling a variety of personalized therapeutic applications.

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Supplementary files

Publication details

The article was received on 10 May 2018, accepted on 11 Jul 2018 and first published on 12 Jul 2018


Article type: Paper
DOI: 10.1039/C8NR03782E
Citation: Nanoscale, 2018, Accepted Manuscript
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    Noninvasive real-time monitoring of local drug release using nano Au-absorbed self-decomposable SiO2 carriers

    L. Fan, J. Yang, K. C. F. Leung, C. Song and Q. Li, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR03782E

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