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Simple Construction of Cu2-xS:Pt Nanoparticles as Nanotheranostic Agent for Imaging Guided Chemo-Photothermal Synergistic Therapy of Cancer

Abstract

Synergistic therapy has attracted intense attention in medical treatment because it can make up for the deficiency of single therapy and greatly improve the efficacy of cancer treatment. However, it remains a challenge to build a simple system to achieve synergistic therapy. In this work, X-ray computed tomography (CT) imaging guided chemo-photothermal synergistic therapy can be easily achieved by simple construction of Cu2-xS:Pt(0.3)/PVP nanoparticles (NPs). The Cu2-xS:Pt(0.3)/PVP NPs can passively accumulate within the tumor site ensured that a large number of Cu2-xS:Pt(0.3)/PVP NPs were brought into the tumor cells, which can be confirmed by the results of cellular uptake, imaging, and nanoparticles biodistribution. It can be verified that the platinum ions could release from Cu2-xS:Pt(0.3)/PVP NPs under 808 nm laser irradiation. Simultaneously, Pt(IV) ions were reduced to Pt(II) ions by excess glutathione and then exhibit chemo-anticancer activities. In addition, Cu2-xS:Pt(0.3)/PVP NPs can be used as effective photothermal agent. The results demonstrated that the efficient tumor growth inhibition effect can be realized from the mice treated with Cu2-xS:Pt(0.3)/PVP NPs under 808 nm laser irradiation by chemo-photothermal synergistic therapy. Furthermore, Cu2-xS:Pt(0.3)/PVP NPs could be thoroughly cleared through feces in a short time, showing high biosafety for further potential clinical translation.

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Supplementary files

Publication details

The article was received on 03 Apr 2018, accepted on 15 May 2018 and first published on 16 May 2018


Article type: Paper
DOI: 10.1039/C8NR02692K
Citation: Nanoscale, 2018, Accepted Manuscript
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    Simple Construction of Cu2-xS:Pt Nanoparticles as Nanotheranostic Agent for Imaging Guided Chemo-Photothermal Synergistic Therapy of Cancer

    L. Dong, P. Zhang, X. Xu, P. Lei, K. Du, M. Zhang, D. Wang , J. Feng, W. Li and H. Zhang, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR02692K

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