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An efficient dye-sensitized NIR emissive lanthanide nanomaterial and its application in fluorescence-guided peritumoral lymph node dissection

Abstract

The emission intensity of near infrared (NIR) emitting lanthanide nanoparticles (LnNPs) is usually limited owing to their small absorption cross section. Although dye sensitization is proved to be an effective way to improve the luminescence intensity of LnNPs, the sensitization effect is fairly limited owing to the simplicity of sensitizer and complexity of energy transfer process, typically involving three steps. In this study, a more efficient sensitizer (Cy7) was chosen to replace the commonly used one (ICG) and the energy transfer process was reduced to two steps by using Yb as emitter ions and Nd as intermediate ions. With Cy7 as sensitizer, sensitization effect was assessed to be better than that with ICG, owing to the higher quantum yield of Cy7. Meanwhile, the Cy7-sensitized NIR lanthanide nanomaterial was proved to be good at deep tissue and low-power excitation bioimaging. Furthermore, the highly-enhanced NIR signal was successfully used in blood vessel imaging and fluorescence-guided peritumoral lymph node dissection in mouse mode.

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Publication details

The article was received on 02 Apr 2018, accepted on 09 Jun 2018 and first published on 12 Jun 2018


Article type: Paper
DOI: 10.1039/C8NR02656D
Citation: Nanoscale, 2018, Accepted Manuscript
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    An efficient dye-sensitized NIR emissive lanthanide nanomaterial and its application in fluorescence-guided peritumoral lymph node dissection

    Q. Liu, X. Zou, Y. Shi, B. Shen, C. Cao, S. Cheng, W. Feng and F. Li, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR02656D

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