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Issue 23, 2018
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Diketopyrrolopyrrole-based carbon dots for photodynamic therapy

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Abstract

The development of a simple and straightforward strategy to synthesize multifunctional carbon dots for photodynamic therapy (PDT) has been an emerging focus. In this work, diketopyrrolopyrrole-based fluorescent carbon dots (DPP CDs) were designed and synthesized through a facile one-pot hydrothermal method by using diketopyrrolopyrrole (DPP) and chitosan (CTS) as raw materials. DPP CDs not only maintained the ability of DPP to generate singlet oxygen (1O2) but also have excellent hydrophilic properties and outstanding biocompatibility. In vitro and in vivo experiments demonstrated that DPP CDs greatly inhibited the growth of tumor cells under laser irradiation (540 nm). This study highlights the potential of the rational design of CDs for efficient cancer therapy.

Graphical abstract: Diketopyrrolopyrrole-based carbon dots for photodynamic therapy

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Publication details

The article was received on 02 Apr 2018, accepted on 10 May 2018 and first published on 11 May 2018


Article type: Paper
DOI: 10.1039/C8NR02643B
Citation: Nanoscale, 2018,10, 10991-10998
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    Diketopyrrolopyrrole-based carbon dots for photodynamic therapy

    H. He, X. Zheng, S. Liu, M. Zheng, Z. Xie, Y. Wang, M. Yu and X. Shuai, Nanoscale, 2018, 10, 10991
    DOI: 10.1039/C8NR02643B

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