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Rare-earth-doped fluoride nanoparticles with engineered long luminescence lifetime for time-gated in vivo optical imaging in the second biological window

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Abstract

Biomedicine is continuously demanding new luminescent materials to be used as optical probes for the acquisition of high resolution, high contrast and high penetration in vivo images. These materials, in combination with advanced techniques, could constitute the first step towards new diagnosis and therapy tools. In this work, we report on the synthesis of long lifetime rare-earth-doped fluoride nanoparticles by adopting different strategies: core/shell and dopant engineering. The here developed nanoparticles show intense infrared emission in the second biological window with a long luminescence lifetime close to 1 millisecond. These two properties make the here presented nanoparticles excellent candidates for time-gated infrared optical bioimaging. Indeed, their potential application as optical imaging contrast agents for autofluorescence-free in vivo small animal imaging has been demonstrated, allowing high contrast real-time tracking of gastrointestinal absorption of nanoparticles and transcranial imaging of intracerebrally injected nanoparticles in the murine brain.

Graphical abstract: Rare-earth-doped fluoride nanoparticles with engineered long luminescence lifetime for time-gated in vivo optical imaging in the second biological window

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Publication details

The article was received on 22 Mar 2018, accepted on 14 Aug 2018 and first published on 23 Aug 2018


Article type: Paper
DOI: 10.1039/C8NR02382D
Citation: Nanoscale, 2018, Advance Article
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    Rare-earth-doped fluoride nanoparticles with engineered long luminescence lifetime for time-gated in vivo optical imaging in the second biological window

    M. Tan, B. del Rosal, Y. Zhang, E. Martín Rodríguez, J. Hu, Z. Zhou, R. Fan, D. H. Ortgies, N. Fernández, I. Chaves-Coira, Á. Núñez, D. Jaque and G. Chen, Nanoscale, 2018, Advance Article , DOI: 10.1039/C8NR02382D

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