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Lipid extraction by boron nitride nanosheets from liquid-ordered and liquid-disordered nanodomains

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Abstract

Atomically thin boron nitride nanosheets are important two-dimensional nanomaterials with great potential in biomedical applications. Understanding the basic interaction mechanisms between lipid domains and boron nitride nanosheets can help clarify the potential risks of these nanomaterials and thus provide guidance on the design of safe biomedical applications. Using molecular dynamics simulations, we demonstrate that the BNNS can disrupt the liquid disordered lipid bilayers much more easily compared to the liquid ordered phases. The potential of mean force profiles calculated from umbrella sampling further explain this adsorption preference. When the BNNS is placed at the boundary of the liquid ordered and liquid disordered nanodomains, disruption of the liquid ordered domains becomes much easier due to the presence of adjacent liquid disordered domains. Our findings provide new insights into the cytotoxicity of boron nitride nanosheets interacting with cellular membranes.

Graphical abstract: Lipid extraction by boron nitride nanosheets from liquid-ordered and liquid-disordered nanodomains

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Publication details

The article was received on 10 Mar 2018, accepted on 21 Jun 2018 and first published on 21 Jun 2018


Article type: Paper
DOI: 10.1039/C8NR02018C
Citation: Nanoscale, 2018, Advance Article
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    Lipid extraction by boron nitride nanosheets from liquid-ordered and liquid-disordered nanodomains

    Y. Zhang, C. Chan, Z. Li, J. Ma, Q. Meng, X. Cheng and J. Fan, Nanoscale, 2018, Advance Article , DOI: 10.1039/C8NR02018C

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