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Issue 19, 2018
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Temperature responsive nanoparticles: poloxamers as a modulator of Förster resonance energy transfer (FRET)

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Abstract

An effective strategy to control the Förster resonance energy transfer (FRET) of a donor/acceptor emitter pair that were attached to a 60 nm poly(propargyl acrylate)(PA) nanoparticle using temperature variations was developed. The size dependent properties of a poly-(ethylene oxide)-poly-(propylene oxide)-poly-(ethylene oxide) (PEO-PPO-PEO) block copolymer (poloxamer) was exploited to vary the spatial separation of the emitters and vary the FRET efficiency. Specifically, a 2% change in FRET efficiency between the donor/acceptor pair was achieved per 1 °C change in temperature from 49 °C to 60 °C when using a poloxamer of 2950 g mol−1 molecular weight, with sections of PPO consisting of 32 repeat units, PEO sections consisting of 12 repeat units and a lower critical solution temperature (LCST) of 58 °C. The methodology presented in this effort is easily extended to other temperature regimes through a judicious choice in poloxamer and corresponding LCST.

Graphical abstract: Temperature responsive nanoparticles: poloxamers as a modulator of Förster resonance energy transfer (FRET)

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Publication details

The article was received on 12 Feb 2018, accepted on 17 Apr 2018 and first published on 26 Apr 2018


Article type: Paper
DOI: 10.1039/C8NR01278D
Citation: Nanoscale, 2018,10, 9401-9409
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    Temperature responsive nanoparticles: poloxamers as a modulator of Förster resonance energy transfer (FRET)

    O. Klep, Y. Bandera and S. H. Foulger, Nanoscale, 2018, 10, 9401
    DOI: 10.1039/C8NR01278D

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