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Issue 24, 2018
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Partner-facilitating transmembrane penetration of nanoparticles: a biological test in silico

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Abstract

Transmembrane penetration of nanoparticles (NPs) promises an effective pathway for cargo delivery into cells, and offers the possibility of organelle-specific targeting for biomedical applications. However, a full understanding of the underlying NP–membrane interaction mechanism is still lacking. In this work, the membrane penetration behavior of NPs is statistically analyzed based on the simulations of over 2.2 ms, which are performed with dissipative particle dynamics (DPD). Influences from multiple factors including the NP concentration, shape and surface chemistry are taken into account. It is interesting to find that, the introduction of a partner NP would greatly facilitate the transmembrane penetration of a host spherical NP. This is probably due to the membrane-mediated cooperation between the NPs. Moreover, the proper selection of a partner NP with specific surface chemistry is of great significance. For example, the best partner for a hydrophilic NP to achieve transmembrane penetration is a Janus-like one, in comparison with the hydrophilic, hydrophobic or randomly surface-decorated NPs. Furthermore, such a partner-facilitating effect in NP translocation also works for a shaped NP although less pronounced. Our results are helpful for a better understanding of the complicated nano–bio interactions, and offer a practical guide to the NP-based drug delivery strategy with high efficiency.

Graphical abstract: Partner-facilitating transmembrane penetration of nanoparticles: a biological test in silico

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Publication details

The article was received on 09 Feb 2018, accepted on 20 May 2018 and first published on 21 May 2018


Article type: Paper
DOI: 10.1039/C8NR01204K
Citation: Nanoscale, 2018,10, 11670-11678
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    Partner-facilitating transmembrane penetration of nanoparticles: a biological test in silico

    W. Wang, R. Yang, F. Zhang, B. Yuan, K. Yang and Y. Ma, Nanoscale, 2018, 10, 11670
    DOI: 10.1039/C8NR01204K

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