Jump to main content
Jump to site search

Issue 18, 2018
Previous Article Next Article

Soft and flexible poly(ethylene glycol) nanotubes for local drug delivery

Author affiliations

Abstract

Nanotubes are emerging as promising materials for healthcare applications but the selection of clinically relevant starting materials for their synthesis remains largely unexplored. Here we present, for the first time, the synthesis of poly(ethylene glycol) (PEG) based nanotubes via the photopolymerization of poly(ethylene glycol) diacrylate and other diacrylate derivatives within the pores of anodized aluminum oxide templates. Template-assisted synthesis allowed the manufacture of a diverse set of polymeric nanotubes with tunable physical characteristics including diameter (∼200–400 nm) and stiffness (405–902 kPa). PEG nanotubes were subjected to cytotoxicty assessment in cell lines and primary stem cells and showed excellent cytocompatability (IC50 > 120 μg ml−1). Nanotubes were readily drug loaded but released the majority of the drug over 5 days. Direct administration of drug loaded nanotubes to human orthotopic breast tumors substantially reduced tumor growth and metastasis and outperformed i.v. administration at the equivalent dose. Overall, this nanotube templating platform is emerging as a facile route for the manufacture of poly(ethylene glycol) nanotubes.

Graphical abstract: Soft and flexible poly(ethylene glycol) nanotubes for local drug delivery

Back to tab navigation

Supplementary files

Publication details

The article was received on 22 Jan 2018, accepted on 27 Mar 2018 and first published on 01 May 2018


Article type: Communication
DOI: 10.1039/C8NR00603B
Citation: Nanoscale, 2018,10, 8413-8421
  • Open access: Creative Commons BY license
  •   Request permissions

    Soft and flexible poly(ethylene glycol) nanotubes for local drug delivery

    B. Newland, C. Taplan, D. Pette, J. Friedrichs, M. Steinhart, W. Wang, B. Voit, F. P. Seib and C. Werner, Nanoscale, 2018, 10, 8413
    DOI: 10.1039/C8NR00603B

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements