Jump to main content
Jump to site search

Issue 12, 2018
Previous Article Next Article

Dynamic self-assembly of DNA minor groove-binding ligand DB921 into nanotubes triggered by an alkali halide

Author affiliations

Abstract

We describe a novel self-assembling supramolecular nanotube system formed by a heterocyclic cationic molecule which was originally designed for its potential as an antiparasitic and DNA sequence recognition agent. Our structural characterisation work indicates that the nanotubes form via a hierarchical assembly mechanism that can be triggered and tuned by well-defined concentrations of simple alkali halide salts in water. The nanotubes assembled in NaCl have inner and outer diameters of ca. 22 nm and 26 nm respectively, with lengths that reach into several microns. Our results suggest the tubes consist of DB921 molecules stacked along the direction of the nanotube long axis. The tubes are stabilised by face-to-face π–π stacking and ionic interactions between the charged amidinium groups of the ligand and the negative halide ions. The assembly process of the nanotubes was followed using small-angle X-ray and neutron scattering, transmission electron microscopy and ultraviolet/visible spectroscopy. Our data demonstrate that assembly occurs through the formation of intermediate ribbon-like structures that in turn form helices that tighten and compact to form the final stable filament. This assembly process was tested using different alkali–metal salts, showing a strong preference for chloride or bromide anions and with little dependency on the type of cation. Our data further demonstrates the existence of a critical anion concentration above which the rate of self-assembly is greatly enhanced.

Graphical abstract: Dynamic self-assembly of DNA minor groove-binding ligand DB921 into nanotubes triggered by an alkali halide

Back to tab navigation

Supplementary files

Publication details

The article was received on 01 Jun 2017, accepted on 31 Jan 2018 and first published on 08 Mar 2018


Article type: Paper
DOI: 10.1039/C7NR03875E
Citation: Nanoscale, 2018,10, 5550-5558
  • Open access: Creative Commons BY-NC license
  •   Request permissions

    Dynamic self-assembly of DNA minor groove-binding ligand DB921 into nanotubes triggered by an alkali halide

    R. Mizuta, J. M. Devos, J. Webster, W. L. Ling, T. Narayanan, A. Round, D. Munnur, E. Mossou, A. A. Farahat, D. W. Boykin, W. D. Wilson, S. Neidle, R. Schweins, P. Rannou, M. Haertlein, V. T. Forsyth and E. P. Mitchell, Nanoscale, 2018, 10, 5550
    DOI: 10.1039/C7NR03875E

    This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements