Jump to main content
Jump to site search


A Fe3+-enhanced NIR-to-NIR upconversion nanocrystal for tumor-targeted trimodality bioimaging

Abstract

Multimodality bioimaging which integrates the merits of two or more imaging techniques in a material have been applied for clinical prognosis and diagnosis for several years. As for in vivo bioimaging, it is important to develop materials whose excitation and emission spectrum lie in the “optical transparent biological window” (750-1000 nm), in which there are minimal autofluorescence, little damage to biosamples and deep tissue penetration ability. Herein, folate conjugated core-shell upconversion luminescence (UCL) nanoparticles (NPs), FA-NaYF4:Yb3+,Tm3+,20%Fe3+@NaGdF4 (FA-Y:Yb,Tm,Fe@Gd) NPs, were synthesized and applied for trimodal imaging, i.e. NIR UCL imaging by the Y:Yb,Tm,Fe core, magnetic resonance and X-ray imaging by the NaGdF4 shell. Folate works as the tumor-target probe. Addition of 20% Fe3+ (in mole) resulted in 20 times increase in the NIR UCL intensity under 980 nm excitation. The mechanism of the Fe3+-resulted in enhancement of NIR UCL efficiency was explored. Methyl thiazolyl tetrazolium (MTT) assay in HeLa cells and histological analysis of healthy viscera sections shows that the proposed NPs display a low biological toxicity.

Back to tab navigation

Supplementary files

Publication details

The article was accepted on 04 Sep 2018 and first published on 14 Sep 2018


Article type: Paper
DOI: 10.1039/C8NJ04248A
Citation: New J. Chem., 2018, Accepted Manuscript
  •   Request permissions

    A Fe3+-enhanced NIR-to-NIR upconversion nanocrystal for tumor-targeted trimodality bioimaging

    Z. An, L. Wang, C. Gao, N. He, Y. Liu, Q. Cai and B. Zhu, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ04248A

Search articles by author

Spotlight

Advertisements