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Issue 18, 2018
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A molecular probe based on pyrimidine imidazole derivatives for stable super-resolution endoplasmic reticulum imaging in living cells

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Abstract

Multi-functional florescent dyes capable of acting as molecular probes in living systems under two-photon microscopy, as well as super-resolution nanoscopy, are of great interest. Herein, a novel donor–π–acceptor (D–π–A) type pyrimidine imidazole derivative with a flexible alkyl chain molecule (EX-1) has been efficiently synthesized through improved Knoevenagel condensation with high yield and relatively large 2PA cross-sections. Furthermore, a cytotoxicity assay and photo-resistance evaluation indicated that such small organic dyes could not only effectively target the endoplasmic reticulum in living cells, but also reveal its ultrastructure under stimulated emission depletion (STED) nanoscopy.

Graphical abstract: A molecular probe based on pyrimidine imidazole derivatives for stable super-resolution endoplasmic reticulum imaging in living cells

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Publication details

The article was received on 07 Aug 2018, accepted on 13 Aug 2018 and first published on 15 Aug 2018


Article type: Letter
DOI: 10.1039/C8NJ03986K
Citation: New J. Chem., 2018,42, 14725-14728
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    A molecular probe based on pyrimidine imidazole derivatives for stable super-resolution endoplasmic reticulum imaging in living cells

    L. Hu, S. Hussain, T. Liu, Y. Yue, J. Liu, Y. Tian and X. Tian, New J. Chem., 2018, 42, 14725
    DOI: 10.1039/C8NJ03986K

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