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Gold-Catalyzed Tandem Reaction of 2-Alkynylanilines, followed by 1, 6-Conjugate Addition to p-Quinone Methides: An efficient access to unsymmetrical Diarylindolylmethanes

Abstract

A simple, mild, catalytic and chemo selective efficient method for the straightforward synthesis of an interesting class of a range of 2-aryl/alkyl-substituted-3-diary indolyl methanes in good to high yields is reported. This atom-efficient method proceeds via gold-catalyzed one-pot sequential intramolecular hydroamination (C-N bond formation) of 2-alkynylanilines followed by 1,6-conjugative addition to p-quinone methides. Here, we report chemoselective conjugative addition i.e., 1,6-conjugative addition to p-quinone methides, aldehyde functional group remains stable 4aj & 4ak.

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Publication details

The article was received on 06 Aug 2018, accepted on 12 Sep 2018 and first published on 13 Sep 2018


Article type: Paper
DOI: 10.1039/C8NJ03955K
Citation: New J. Chem., 2018, Accepted Manuscript
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    Gold-Catalyzed Tandem Reaction of 2-Alkynylanilines, followed by 1, 6-Conjugate Addition to p-Quinone Methides: An efficient access to unsymmetrical Diarylindolylmethanes

    R. Jillella, D. H. Oh and C. Oh, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ03955K

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