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New insights for the preparation of cytidine containing nucleotides using a soluble ether-linked polyethylene glycol support

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Abstract

We proposed an improved methodology for soluble PEG-supported synthesis of 5′-nucleotide derivatives from cytidine using a carboxylethoxy linker. Compared to our previous work, no by-product is formed during cleavage from the support and dialysis is not required anymore for purification.

Graphical abstract: New insights for the preparation of cytidine containing nucleotides using a soluble ether-linked polyethylene glycol support

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Publication details

The article was received on 27 Jul 2018, accepted on 10 Sep 2018 and first published on 10 Sep 2018


Article type: Letter
DOI: 10.1039/C8NJ03753A
Citation: New J. Chem., 2018, Advance Article
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    New insights for the preparation of cytidine containing nucleotides using a soluble ether-linked polyethylene glycol support

    A. Depaix, J. Puy, B. Roy and S. Peyrottes, New J. Chem., 2018, Advance Article , DOI: 10.1039/C8NJ03753A

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