New insights for the preparation of cytidine containing nucleotides using a soluble ether-linked polyethylene glycol support

Anaïs Depaix; Jean-Yves Puy; Béatrice Roy; Suzanne Peyrottes

doi:10.1039/C8NJ03753A

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New insights for the preparation of cytidine containing nucleotides using a soluble ether-linked polyethylene glycol support†

Anaïs Depaix,^a Jean-Yves Puy,^a Béatrice Roy

^a and Suzanne Peyrottes

*^a

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* Corresponding authors

^a Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS, Université de Montpellier, ENSCM, Campus Triolet, cc 1705, Place Eugène Bataillon, 34095 Montpellier cedex 5, France
E-mail: suzanne.peyrottes@umontpellier.fr

Abstract

We proposed an improved methodology for soluble PEG-supported synthesis of 5′-nucleotide derivatives from cytidine using a carboxylethoxy linker. Compared to our previous work, no by-product is formed during cleavage from the support and dialysis is not required anymore for purification.

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Article information

DOI: https://doi.org/10.1039/C8NJ03753A
Article type: Letter
Submitted: 27 Jul 2018
Accepted: 10 Sep 2018
First published: 10 Sep 2018

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New J. Chem., 2018,42, 16441-16445

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New insights for the preparation of cytidine containing nucleotides using a soluble ether-linked polyethylene glycol support

A. Depaix, J. Puy, B. Roy and S. Peyrottes, New J. Chem., 2018, 42, 16441 DOI: 10.1039/C8NJ03753A

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New Journal of Chemistry

New insights for the preparation of cytidine containing nucleotides using a soluble ether-linked polyethylene glycol support†

Abstract

Supplementary files

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New insights for the preparation of cytidine containing nucleotides using a soluble ether-linked polyethylene glycol support

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