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Assembling of hydrophilic and cytocompatible three-dimensional scaffolds based on aminolyzed poly(L-lactide) single crystals

Abstract

Poly(L-lactide) has a good biocompatibility and processability, but its surface lacks the proper hydrophilicity for cell growth and proliferation which could obstacle its use as a tissue engineering scaffold. Surface aminolysis was reported to improve the surface hydrophilicity and cytocompatibility of polymers. However, aminolysis of 2D substrates was achieved on the surface to only low depths, and aminolysis of 3D scaffolds did not guarantee homogenous distribution of amine functionality at the surface. These problems can be addressed in this work by developing 3D scaffolds based on pre-aminolyzed poly(L-lactide) single crystals. Scaffolds were fabricated by using the simple compression molding salt leaching technique in the absence of heat or gluing materials. Mechanical and morphological studies showed that the scaffolds are mechanically stable with well interconnected open-porous structures. The ninhydrin test assured a homogenous spatial distribution of the amine groups. The biological behavior of the scaffolds was investigated by seeding them with the fibroblast cells. The aminolyzed single crystals offered a better interface for fibroblast to adhere, proliferate and migrate than pristine ones and hence could result in a promising 3D porous structure for tissue engineering applications.

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Publication details

The article was received on 27 Jun 2018, accepted on 10 Sep 2018 and first published on 10 Sep 2018


Article type: Paper
DOI: 10.1039/C8NJ03205J
Citation: New J. Chem., 2018, Accepted Manuscript
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    Assembling of hydrophilic and cytocompatible three-dimensional scaffolds based on aminolyzed poly(L-lactide) single crystals

    A. Bakry, M. S. A. Darwish and A. M. A. El Naggar, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ03205J

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