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Dual responsive salen-type Schiff bases for the effective detection of L-arginine via a static quenching mechanism

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Abstract

L-Arginine is one of the most important amino acids and plays a key role in diagnostic studies. Herein, we report four salen-type Schiff base fluorimetric/colorimetric sensors for the rapid detection of L-arginine. Substituents play a major role in the sensing mechanism of probes with the nitro-substituent bearing probe showing the highest efficiency. A 1 : 2 complexation between all the probes and the analyte was evidenced from the absorption titrations; and the fluorescence studies revealed a quenching phenomenon occurring during complex formation. From the life time measurements, the nature of quenching was found to be static and the formation of a ground state complex was confirmed. DFT calculations done at the B3LYP/TZVP level of theory corroborated the experimental findings and further established the proton transfer from the probe to the analyte during the complex formation.

Graphical abstract: Dual responsive salen-type Schiff bases for the effective detection of l-arginine via a static quenching mechanism

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Publication details

The article was received on 29 May 2018, accepted on 27 Jun 2018 and first published on 28 Jun 2018


Article type: Paper
DOI: 10.1039/C8NJ02657B
Citation: New J. Chem., 2018, Advance Article
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    Dual responsive salen-type Schiff bases for the effective detection of L-arginine via a static quenching mechanism

    N. Mohan, S. S. Sreejith, P. M. S. Begum and M. R. P. Kurup, New J. Chem., 2018, Advance Article , DOI: 10.1039/C8NJ02657B

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