Jump to main content
Jump to site search


Selective binding of methotrexate to monomeric, dimeric and polymeric cyclodextrins

Author affiliations

Abstract

The difference in the complexation affinity of methotrexate (MTX) to the naturally occurring α-, β- and γ-cyclodextrins (CDs) as well as to the novel synthetic dimeric and polymeric β-cyclodextrins was revealed. The effect of CD structure complicity on the complexation with MTX was discussed. It was found that β-CD and dimeric β-CD display a higher binding ability to MTX. Dimeric β-CD acts as a ditopic host forming rather stable 1 : 2 inclusion complexes with MTX. In contrast, the binding of MTX with polymeric β-CD is not sufficient due to the possible steric hindrance. The thermodynamics and binding modes of CDs with MTX were obtained and analyzed. The influence of buffer pH on the complexation process was considered. The binding affinity of β-CD to different ionized forms of MTX was examined using the capillary electrophoresis technique.

Graphical abstract: Selective binding of methotrexate to monomeric, dimeric and polymeric cyclodextrins

Back to tab navigation

Supplementary files

Publication details

The article was received on 28 May 2018, accepted on 14 Jul 2018 and first published on 08 Aug 2018


Article type: Paper
DOI: 10.1039/C8NJ02632G
Citation: New J. Chem., 2018, Advance Article
  •   Request permissions

    Selective binding of methotrexate to monomeric, dimeric and polymeric cyclodextrins

    I. Kritskiy, R. Kumeev, T. Volkova, D. Shipilov, N. Kutyasheva, M. Grachev and I. Terekhova, New J. Chem., 2018, Advance Article , DOI: 10.1039/C8NJ02632G

Search articles by author

Spotlight

Advertisements