Jump to main content
Jump to site search


Novel crabby biological-based glycoluril with alkane sulfonic acid pendings as a reusable nanostructured catalyst: Application for synthesis of new mono and bis-spiropyrans under mild and green conditions and in vitro biological performance

Abstract

Herein a novel crabby biological-based glycoluril with sulfonic acid tags, namely glycoluril tetrakis (butane-1-sulfonic acid) (GTBSA) prepared in nano-size and fully characterized by several techniques such as: 1H and 13C NMR, Fourier transform infrared spectroscopy (FT-IR), CHNS analysis, Mass spectra, X-ray diffraction (XRD), thermal gravimetric analysis (TGA), differential thermal gravimetric (DTG), scanning electron microscope (SEM) and transmission electron microscopy (TEM). It is proved that this novel nanostructured catalyst is an efficient catalyst for the synthesis of novel spiropyrans via one-pot multi-component condensation of isatine, naphthalene-2,3-diol or 2,5-dihydroxycyclohexa-2,5-diene-1,4-dione, malononitrile or 1,3 di-carbonyl compounds in refluxing water. Mild reaction conditions, easy work-up, good to excellent yields and reusability of catalyst are major advantages of described procedure. Results from DPPH radical scavenging assay showed that the synthesized compounds have eminent antioxidant efficacies (IC50; 0.16±0.01 to 0.55±0.02 mg ml-1). Moreover, in vitro antibacterial activity of the compounds was assessed against 4 Gram-positive and Gram-negative bacterial strains by disc diffusion method. Results showed that the compounds 2S and 3S possess high ability for growth inhibition of E. coli, which is comparable to the positive control Gentamicin.

Back to tab navigation

Supplementary files

Publication details

The article was received on 18 May 2018, accepted on 10 Jul 2018 and first published on 11 Jul 2018


Article type: Paper
DOI: 10.1039/C8NJ02470G
Citation: New J. Chem., 2018, Accepted Manuscript
  •   Request permissions

    Novel crabby biological-based glycoluril with alkane sulfonic acid pendings as a reusable nanostructured catalyst: Application for synthesis of new mono and bis-spiropyrans under mild and green conditions and in vitro biological performance

    M. zarei, H. Sepehrmansourie, M. A. Zolfigol, R. Karamianc and M. Hamed, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ02470G

Search articles by author

Spotlight

Advertisements